Question: dear doctor, Please, help me please! My sister's liver problems. In 1991, she had hepatitis A, and since then at times the liver made itself felt. But this year, in December, we seriously ill and my mother died, and while she was in the hospital, my sister took care of her. Naturally – stress, virtually no food: In late December, my sister's condition had deteriorated: yellowed whites of the eyes, skin, appeared pain in the right hypochondrium. January 14, 2008 it was put in hospital Kotovsk such analysis: Biochemistry: total bilirubin – direct bilirubin 45,6 – 5,7 indirect bilirubin – 39.9 total protein – 78 urea – 3,63 creatinine – 0.047 ACT — 24 ALT – 10REZULTATY Ultrasound: Liver not enlarged in size, smooth contours, echogenicity slightly increased, the structure is homogeneous. EPV – 20 mm BB – 11 mm. Diffuse changes in the liver. Gall bladder wall thickened to 3.5 mm in size is not increased, the contents of a homogeneous, without concretions. Treated in hospital for 11 days, received intravenous glucose and esentseale. She also went to a consultation in Tambov, testing. As a result, to be discharged on Jan. 25, 2008 results were as follows: Biochemistry: bilirubin total – 24.6 total protein – 74 urea – 3,26 creatinine – 0.050 ACT – 12 ALT – 11Timolovaya sample – 1Sulemovaya sample – 1,6 PTI – 84PTV — 19Ibrinogen – 3Posle advice from infectious diseases and analysis, the presence of hepatitis B and C have been identified. After his discharge condition improved, proteins yellowing until the end of the day, was registered esentseale capsules. However, a week later the state began to deteriorate again: once again appeared and the severity of pain in the right hypochondrium, yellowed whites of the eyes, skin, appeared bitter taste in the mouth, sometimes dizziness, rapid utomlyaemost8 February 2008 again went to consult a gastroenterologist in Tambov, testing . The results were these: Biochemistry: bilirubin, total – 41 Bilirubin direct – 7 of indirect bilirubin – 34 ACT – 22 ALT – 10Timolovaya sample – 3REZULTATY Ultrasound: Liver is usually sharp edges, with clear smooth contours. Dimensions PZR right lobe 135 mm, left – 99 mm. Normal echogenicity, ehostruktura homogeneous, fine-grained, without focal formations. Vascular pattern of the liver clearly expressed to the periphery, portal vein diameter of 15 mm, in the projection gate liver enlarged lymph nodes were not visualized. Biliary ways structural, not extended, without focal entity and concretions. Gall bladder size increased, extended. The walls are thickened to 3 mm. Contents anehogennoe, homogeneous, without visible shadows concretions. Diagnosis: Chronic hepatitis of unknown origin (?), Gilbert's syndrome (?) T. that is all under question, treatment, of course, not appointed. What can it be? Is it dangerous? What do we do now, what tests to pass and what treatment? Help please! Advance – thank you very much.
Answer: Apparently, this is Gilbert's syndrome + biliary dyskinesia. In this case, can facilitate being sedatives (best Corvalol or valokordin), security measures, tyubazhi (http://doktor. Ru / qa / gastro / article. Html? Id = 52169). What is Gilbert's syndrome. Syndrome (but not the disease!) Gilbert, or benign hyperbilirubinemia – a condition which is based on an innate weakness of some enzyme systems. Treatment _not_ trebuetsya_ (yes, and it does not exist – http://doktor. Ru/qa/15982/qa. Html? Id = 86649). This condition is not all doctors are well aware, it is often confused with chronic hepatitis and prescribe unnecessary treatment. In contrast to chronic hepatitis yellow eyes and skin fickle (intermittent nature), the liver is increased (or increased very slightly), the spleen does not increase. Biochemical blood test reveals only an increase in bilirubin, the results of all other liver function tests have not changed. Patsietov bother most asthenic or autonomic disorders. Strongholds of the recognition of Gilbert's syndrome (and distinguishing it from hepatitis B) are as follows: – found mostly in boys and young men (10-20 years) – Indications of a hereditary predisposition (family affair) – Initially, transient jaundice is detected in early childhood – Jaundice casual and neintensivnaya (mostly yellowing of the eye sclera) – The emergence of (increased), yellowing of sclera with fatigue, the emergence of infectious diseases – Inconsistent feeling of heaviness in the right hypochondrium – slight enlargement of the liver – blood bilirubin exceeds the norm by not more than 3-4 times (mainly due to the free, unconjugated fraction) – bilirubin in the blood increases when the full or partial starvation – liver enzymes (ALT, AST) in the normal range – in the urine bilirubin is not found.