Question: Dear doctor! It is clear that giving advice in absentia – is extremely difficult to treat – it is impossible, and the amount set out for part-time consulting big. Given your professionalism Gastroenterology – Hepatology, thank you in advance for any your answer to me. I learned about the possibility of consulting the site http://www. doktor. ru / qa / gastro, so my questions to you with some cuts and placement as on the website. Dear doctor, is it possible to understand what causes the disease, to determine what it is and assign treatment? Son, 23 years old. Do not drink, does not smoke, not prickly. In February-March 2007, after twice endured influenza (?) Escalated mycoplasmal bronchitis (interstitial pneumonia) (anti-Myc. Pneumonia, Ig G titer silnopolozh, anti-Chl. Pneumonia, Ig G, Ig M-put. " experience "- about 2 years old), and while taking summameda fever (37,8), sallow face, urine acquired shade beer, cloudy, chair-light. Weakness, fatigue, irritability, no appetite, lost weight, body skin – pale, with yellowish tinge, dryish skin. Antibiotics were canceled. Results of Biochemistry and wedge an. blood revealed the increase in the amount of bilirubin, ALT, AST, GGTT, monocytes, leukocytes, reduction of lymphocytes, neutrophils, low ESR (see table).. Blood tests for autoimmune hepatitis (25. 04. 07 and 24. 10. 07) – autoantibodies were detected (Technition medico-genetic. RSMU technology). An blood for hepatitis viruses A, B, C, D, E, TTV of 21. 04. 2007. (By ELISA and PCR) were found. An blood for hepatitis viruses B, C, TTV of 24. 10. 2007. (By ELISA and PCR) – TTV DNA detected by PCR, Qual. analysis. * PCR, HepB C (1999, RNA C, qty. – Is found) Repeated analysis – PCR and ELISA – hepatitis C virus and antibodies to it is not detected and cut-t 1999 ". was regarded as a false positive. Thyroid gland – in the norm. Biochim. Al. Blood: Ultrasound 28. 04. 07 Ultrasound 17. 12. 07 07. 04. 07 21. 04. 2007 08. 06. 07 04. 10. 2007 13. 12. 2007 Referee rdg. ALT 41 66 47 28 21 <41 U / l 40 AST 57 89 40 25 25 <37 U / l 39 Bil Society. 27 28.9 47.7 39.6 35.2 3. 4-17. 1 mmol / l 45 Beal Ave 9 12 12.2 13.9 12.8 <7. 9 mmol / l 9,7 Gamma-GT 222 219 95 87 62 <49 U / l F. Schel 168 237 154 137 117 40-150 U / l Iron – - 21.1 20 21.93 11,64-31, 3 mmol / l 14,4 Lat zhelezosvyaz Choco-Th – - 43.8 46.4 51 20-62 mmol / L Transferrin – - 3,09 2,75 2,83 2,00-4,00 g / l. Ferritin – - 36.9 60.9 – 20-250 mg / l transferrin saturation% – - 27.2 28.9 30.8 15-50% C-REACT protein – 5.0 18.1 1.9 0.0 -5.0 mg / l cholesterol 3.46 3.64 2.77 3.53 3.94 3,16-5,59 mmol / l Albumin 44.1 45 41 46 45 35-50 Alpha-1-Globe 2 , 4 2,8 2,6 2,5 1,8 1,0-3,0 g / l. Alpha-2-Globe 7.3 6.4 7.3 8.4 7.1 6,0-10,0 g / l beta-Globe 8.7 8.3 7.8 8.1 8.4 7,0-1,001 g / l Gamma-Globe 11.5 12.3 15.8 11.2 11.4 8.0 — 16,0 g / l Creatinine 110 110 88 99 85 62-115 mmol / l Glucose 5.2 5 4.6 5.3 4.8 3,89-5,83 mmol / L Total protein 74 75 74 76 74 64 — 83g / l. Homocysteine 16,27 3,70-13,90 mmol / l IgE 338. 3 0-150 kIU / L Antibodies to tireperroksidaze 18 0-40 IU / ml Klin. Al. blood Ultrasound 28. 04. . 07 Ultrasound 17. 12. 07Parametry 07. 04. 07 21. 04. 2007 08. 06. 07 04. 10. 2007 13. 12. 2007 Referee rdg. Hematocrit 45.7 44.7 47.5 47.1 47.6 39-49% Hemoglobin 16.2 15.4 16.4 16.3 16.9 13,2-17,3 g / dL RBC 5.78 5 , 57 5,87 5,98 5,93 4,3-5,87 million / microL MCV (Wed volume er) 79 80 81 79 80.3 80-99fl MCN (Wed previous article Hb in Riyadh) 28 27,6 27 9 27.3 28.5 27-34g/dl MCHC (Wed conc. Hb in er) 35.4 34.5 34.5 34.5 35.5 32-37 g / dL Platelets 275 236 324 297 292 150 — 400tys/mkl Leukocytes 4.95 7.90 6.80 9.55 8.49 4,5-11 thousand / mcl Neutrophils 42 20 34.2 58.1 42.2 48-78% Lymphocytes 35 62 49.1 31 1 41,2 19-37% Monocytes 14 21 13.5 10.3 9.2 3-11% Eozinofily 2 2 2.9 2.3 6.9 1-5% basophils 0 1.1 0.3 0 , 2 0,5 ESR less than 1% (by Vestergrenu) 1 – 1 2 1 menee15mm / h ultrasonography (17. 12. 2007): Liver – increased size of the Upper-Lower right lobe of the right cp / clavicular line-13-smVerhne Lower size the left lobe of the right parasternal line-8 cm ECHO-structure of the parenchyma-grained, moderately heterogeneous. ECHO-gennost parenchyma-reduced. Focal amended. – NetVnutripechenochnye vessels-N, intrahepatic bile ducts-N. Choledochitis-0, 5 cm, portal Vienna 1, 2, see Gall bladder, 7×2, 5 cm, the walls thickened to 0, 5 cm, compressed, content-NPodzheludochnaya iron-NSelezenka-raised, S-70 cm, the edges are rounded. Conclusion: Diffuse changes in the liver. Chr. beskamenny cholecystitis (cholesterosis?). The increase in the spleen. Ultrasound (28. 04. 2007) Liver – not increased the size of the Upper-lower right lobe of the right cp / clavicular line-10, 5 smVerhne-lower size of the left lobe of the right parasternal line-5, 5 cm ECHO-structure of the parenchyma-N ECHO-gennost parenchyma-N focal amended. – NetVnutripechenochnye vessels-N, intrahepatic bile ducts-N. Choledochitis-0 4 cm, portal Vienna 1, 1, see Gall bladder-8 x 3 cm, the walls are not changed, the content-anehogennoPodzheludochnaya iron-NSelezenka is not increased, S-60 cm Conclusion: The signs of colitis. Immunogram (25. 04. 2007) – Lack of T-suppressor level. High levels of NK-cells in perifiricheskoy blood. Expressed lack of IgG in serum. Reduced levels of neutrophil phagocytosis. Received treatment (all prescribed by a doctor, April-December): w / vitamins, in / in miksidol, w / medical ozone, Roncoleukin n / a, laser nadvenno, geptral, ursofalk. Geptral (2 tables) and ursofalk (2 Caps at Night) takes now. Following a course of treatment over the next 5 months (April-October) is very slow improvement in some indices of blood. A better feel (cough, which lasted about 2 years old – stopped in the lungs – without pathology) December 2007 – well-being has worsened again, on the face yellowish skin, even thinner. No appetite, weakness, fatigue, irritability. Works, is raising her daughter. In terms of the survey (until 28 December): – ultrasound to determine the function of the gall bladder and be retested for hepatitis viruses (PCR and ELISA). Previously: (main): Resection of small intestine (at the age of 1, 5 days). Chr. cholecystitis. Gastroduodenitis. Polyvalent allergy (hay fever from April – October, allergies, fungal, bacterial). Recurrent urticaria. Secondary immune deficiency (?). In 1994, hospital. Cervical cholecystitis. Jet pancreatitis. Toxic-allergic hepatitis (?). (Och. high values of alkaline phosphatase (until 2200), GGT, ALT, AST. The true cause and the diagnosis is not reliably determined). Tests Used x blood for the period 1998-2006, the city, except almost always slightly elevated values of alkaline phosphatase, bilirubin, frontier values, or some elevated ALT and AST, and without a sharp deterioration in other indicators, but is constantly "on the verge" , or just "beyond", except in periods of acute illness. Wellbeing in the period 2002-2006. – the fairly decent, given the "tail" of disease. All the main discharge (hospital) in 1984 – on his hands. What happened? 1. 1. "Drug" hepatitis? -Almost a year since the acute onset of disease, cure has not come. 2. Because of the weak immune response (judging by the cut-m tests, the work of the immune system and disorganized) – tests for detection of viral infection provide a negative reaction. But he himself viral hepatitis caused by hepatitis B virus itself, or epshteny bar (povyshen. titles in 2002.), Or herpes (obnar. types VI, II) or other viruses, does its work? 3. Reasons number 1 and number 2, together give a picture. Do not understand where the cause and where the investigation. 4. As a result of long-term preservation of cholestasis, and came suddenly such changes, as identified by ultrasound 17. 12. 2007 and is not detected at ultrasound in April, May and October 2007. earlier? 5. Or newly acquired TTV? (read that this virus is almost "home", does not cause liver damage. I doubt it). 6. Alarmed that in the wake of and ongoing therapy, despite improvements in some indices of blood and a transient improvement in well-being, in general – unstable dynamics or nonpositive dynamics. Ultrasound showed changes in the liver, gallbladder, enlargement of the spleen. This feeling also create indices of lymphocytes, monocytes, neutrophils, leukocytes in blood analyzes perifiricheskoy extremely slow decrease in GGT, "jumped" reactive protein and does not reduce the bilirubin level, cut-you ultrasonography (17. 12. 2007.) After and against the backdrop of the ongoing therapy. 6. By Gastroenterology (Hepatology) for the period April-December approached. And if only very briefly – this was not yet. What, how and with what to treat? Gall with its bend in the bottom third? Hepatitis? Would you take up this puzzle? Or can recommend a qualified specialist? Thank you for your attention, with respect, Nadezhda. 21. 12. 2007.
Answer: At the site of the request has been received. With a weak immune response, the number of viruses in the blood is growing and they are found (another thing – antibodies). What prevents to make tagging a liver biopsy?